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KMID : 1100220120110040111
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Dementia and Neurocognitive Disorders
2012 Volume.11 No. 4 p.111 ~ p.117
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Vitamin D Deficiency and Cognitive Dysfunction
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Moon Yeon-Sil
Han Seol-Heui
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Abstract
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Vitamin D is not a true vitamin but a fat-soluble steroid prohormone that has long been known for its important and diverse role in the biological system. Many studies have revealed that vitamin D deficiency is linked with an increased risk of autoimmune diseases, cardiovascular diseases, cancers, type II diabetes and infectious diseases. Vitamin D3 is transformed to its active form, 1, 25-dihydroxyvitamin D3, through metabolisms in the liver and kidney. 1, 25-dihydroxyvitamin D3 interacts with its vitamin D receptor, and the brain is now known to have vitamin D receptors and 1α-hydroxylase. Several lines of evidences suggest vitamin D deficiency is associated with cognitive impairment and dementia, however, its position in cognitive function is still in its infancy. Vitamin D deficiency is a reversible condition and can be easily treated with supplements. Randomized controlled trials of vitamin D supplementation in patients with neurodegenerative conditions are needed.
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KEYWORD
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Vitamin D deficiency, Cognition, Alzheimer’s disease (AD)
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